In this article I analyse the players looking to be the next to add their names to the illustrious list:
Most neutral tennis fans will be hoping that the next man to make the biggest breakthrough in tennis will be coming from this bracket.
Milos Raonic is currently the leading light from a generation which had the misfortune of coming through just a few years behind the likes of Nadal, Djokovic and Murray. The Canadian has made impressive progress in the past 12 months, reaching his first Masters 1000 final on home turf and establishing himself as a top ten competitor since. With his big serve, big forehand and improving net skills, Raonic's best shot, on paper, looks to be Wimbledon.
Grigor Dimitrov has slowly been working his way up the rankings too, netting three ATP titles since joining up with Roger Rasheed, and reaching his first Grand Slam quarter-final earlier this year in Australia. Dubbed "Baby-Fed", the Bulgarian is at his best on hard courts but has the skills to be a threat on all surfaces, as evidenced by his win over Djokovic on the clay of Madrid last year. Still, I'm looking at Melbourne or New York as the most likely source of his first major.
Kei Nishikori is 24 now but still improving. The Japanese showed in the Madrid final, where he was within touching distance of toppling Rafa for his first Masters 1000 title, why he's so highly thought of. Nishikori's biggest hurdle before he can achieve Grand Slam success is to sort out the physical problems that have dogged him throughout his career, not least in the aforementioned Madrid defeat, but if he does, you can expect him to be a big threat at Roland Garros in particular.
Beyond these three, you're looking at the likes of Dominic Thiem, Jiri Vesely and Nick Kyrgios, who are making impressive progress further down the rankings. Jerzy Janowicz holds a much higher profile, having reached the semi-finals of Wimbledon in 2013, and he certainly has the raw talent to come into the equation as well.
The next category focuses primarily on three former Grand Slam finalists, Jo-Wilfried Tsonga (Australian Open 2008), Tomas Berdych (Wimbledon 2010) and David Ferrer (Roland Garros 2013).
Tsonga is capable of the kind of tennis you need to beat the star players, with his comeback win over Federer at Wimbledon in 2011 springing to mind, but has never had the focus to keep it up for two solid weeks. His form in the past 12 months has been worrying, but it's not out of the question that the stars could align for him one day.
Berdych has been branded as a perennial choker by harsher members of the tennis community, but he has the weapons to threaten anyone - just look at his wins over Federer and Djokovic en route to that Wimbledon final - and if a couple of the big names slip up, the towering Czech will be at the front of the queue looking to capitalise.
Even David Ferrer doesn't believe that he'll win a Grand Slam title before he retires, and I don't think many people would argue with him. With a poor record against the Big Four and age not exactly on his side, the only vaguely realistic chance of the Spanish Terrier making the big breakthrough is at Roland Garros, with a helping hand from some 'spoilers' in the early rounds.
One year ago, Stanislas Wawrinka was very much in this category, having never made it past the quarter-finals of any of the four blue riband events, and only really flirting with the top ten, yet he arrives in Paris this year as a Grand Slam champion. Despite the emergence of the Swiss at age 28, this remains the least likely source of a new winner, with John Isner, Richard Gasquet and Ernests Gulbis among the most likely to spring a surprise. Isner's big serve could see him challenge on the grass of Wimbledon if he can fire on all cylinders for two weeks, but I wouldn't bet on it.
Who do you think will be the next new Grand Slam champion in men's tennis? Vote in the poll and leave comments below.
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